New Studies on the Temporal Dynamics of Gene Expression

Highlights from a Nature Reviews Neuroscience (12/2011) writeup

  • Eighty percent “of the genes examined are differentially regulated across brain regions (reflecting anatomical differences) and/or over time.”
  • “[T]he greatest regional differences in expression occur during prenatal development.”
  • The authors were able to use their data set “generate spatio-temporal expression trajectories of genes associated with particular developmental processes or diseases, such as schizophrenia or autism spectrum disorder.”
  • In a second study, researchers were able to note “significant changes in expression throughout development and identify a consistent architecture of transcription across subjects from different races, despite the large number of genetic polymorphisms among them.”
  • Rate of gene expression increase again after age 50 “when it rises again mirroring the changes in gene expression that are seen in early postnatal life.”

References

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This entry was posted in Gene expression by Constance A. Cummings. Bookmark the permalink.

About Constance A. Cummings

Constance A. Cummings, PhD, is Project Director of the non-profit Foundation for Psychocultural Research, which supports and advances interdisciplinary research and scholarship at the intersection of brain, mind, culture, and mental health and illness. She is co-editor (with Carol Worthman, Paul Plotsky, and Dan Schechter) of Formative Experiences: The Interaction of Caregiving, Culture, and Developmental Psychobiology (Cambridge University Press, 2010) and (with Laurence Kirmayer and Rob Lemelson) the forthcoming Re-Visioning Psychiatry: Cultural Phenomenology, Critical Neuroscience, and Global Mental Health (Cambridge, 2015). She received her doctorate in theoretical linguistics from New York University.

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